Macrophage-Targeted Photodynamic Therapy

Vascular-Targeted Photodynamic Therapy (VTP)

Photodynamic therapy: a targeted therapy in periodontics.

The oral cavity is colonized by a large number and highly diversified communities of micro-organisms. Bacterial biofilm present on tooth or root surface is a major cause of gingivitis and periodontitis. Chemical antimicrobial agents are widely used in prophylactic and therapeutic regimens for dental plaque related diseases, which are among the most common human infections. As these agents are d...

Somatostatin Analogues for Receptor Targeted Photodynamic Therapy

Photodynamic therapy (PDT) is an established treatment modality, used mainly for anticancer therapy that relies on the interaction of photosensitizer, light and oxygen. For the treatment of pathologies in certain anatomical sites, improved targeting of the photosensitizer is necessary to prevent damage to healthy tissue. We report on a novel dual approach of targeted PDT (vascular and cellular ...

Photodynamic Quenched Cathepsin Activity Based Probes for Cancer Detection and Macrophage Targeted Therapy

Elevated cathepsins levels and activities are found in several types of human cancer, making them valuable biomarkers for detection and targeting therapeutics. We designed small molecule quenched activity-based probes (qABPs) that fluoresce upon activity-dependent covalent modification, yielding cell killing by Photodynamic Therapy (PDT). These novel molecules are highly selective theranostic p...

V ascular targeted photodynamic therapy ( VTP )

Introduction Studies in our laboratory focus on development of vascular targeted photodynamic therapy (VTP) based on bacteriochlorophyll derivatives as photosensitizer drugs, elucidation of its mechanism of action and development of new applications for photodynamic therapy (PDT) such as treatment of Extrauterine Pregnancy (EUP). These studies are in collaboration with Prof. Avigdor Scherz Dept...